Saturday, March 14, 2009

Thank Gazillions

Is a gazillion a real number? No it is not, but it is used euphemistically as an indefinitely large number. With our national debt standing at about ten to the power thirteen dollars I say we have reached a gazillion of debt. The French word for Gas is Gaz, so perhaps we are not out of gas quite yet as we can invent the engine that runs on gazillions of paper money.

Talking about numbers, I just read in the Sacramento Bee that in 2008 the number of new vehicles sold in the State of California totaled 1,447,460 down from 1.881,030 in 2007. This means that 433,570 fewer vehicles were sold last year than the year before. In fact the sales of new vehicles in 2008 were the lowest since 1993. The California New Car Dealers Association is predicting some 15.1% fewer new car sales in 2009 with an expected figure of 1,229,000. With all the closures of new car dealerships in Marin County I would estimate that the sales of new vehicles in our county will plunge even further.

Superficially this is good news for the environment, fewer vehicles means fewer carbon emissions, excepting that we need new more efficient vehicles and need to get those fool size SUVs off the road. Also the county as well as the state depends heavily on sales taxes collected from new vehicle sales and the diminished source of government revenue is causing all sorts of ripple effects on the level of basic services we expect from our governments. The ripple is getting so pronounced we may all have to trade down to drinking ripple. Fine wines are also no longer selling in the volumes previously produced. People are trading down to less expensive wines, however on aggregate wine consumption in California is still increasing. Production volume of wines in California increased by 2.5% in 2008. Oregon had us Golden Staters way beat by increasing their wine production by 9.3%.

All these numbers are making my head spin just as if I had drunk a jug of ripple. We are trading down on wine and we are not trading down on the size of our vehicles. My solution to this is the “ultimate stimulus package” of a free Corolla with the purchase of ten cases of Corona. My friend Dave who is my co-host on blog talk radio each Wednesday, bought a brand-new Saab now that that this GM company is in bankruptcy in Sweden. Dave is a very bright MIT engineer and he is willing to risk that parts and service will be hard to get for the substantial discount he received in buying the new Saab. I just hope Saab does not stand for Send Another Able Body when the car breaks down and I have to help push it.

It also seems that another of the Generals in the DOW Industrials has drunk too much ripple. Just this week General Electric’s market capitalization dropped to a low of 89 billion dollars and they cut their dividend by two thirds. GE had a market capitalization in excess of 500 billion dollars or almost a gazillion back in July 2000. I just remembered the Y2K ad that was “yes to KIA”, if only we had bought those small cars we would not have today’s headache.

Wednesday, March 4, 2009

Thank Goats

Has the green machine lost his mind thanking old Billy for helping save the planet. I started thinking of goats a couple of weeks ago when I received this email at work that a company in Framingham Massachusetts has received FDA approval for a biological drug that was recovered from goat’s milk in genetically modified goats. The drug is a protein called Antithrombrin and is used to untangle blood clots. There are approximately one in five thousand patients in the USA that have a genetic disorder of not producing antithrombrin and are at high risk during surgeries or pregnancy. The company chose the route of using genetically modified goats rather than modifying ecoli or Chinese Hamster Ovary cells to express the protein. Ecoli and Chinese Hampster Ovary cells are commonly used to make biological drugs that Genentech, Amgen, J&J and other sell.

A herd of one hundred and fifty genetically modified goats in Massachusetts express the two hundred and twenty pounds of Antithrombrin protein that otherwise would otherwise have to be produced from every drop of blood that is donated in the USA each year. These are very special goats and I bet you they have special herders who make sure they do not escape from their farm where they are fed better food than your average goat. A female goat produces about eight pounds of milk a day and will do so for approximately three hundred day during lactation. Therefore a single goat will produce two thousand four hundred pounds of milk a year. The herd of one hundred and fifty goats will therefore produce three hundred and sixty thousand pounds of milk a year. The concentration of the Antithrombrin protein in the goat’s milk prior to purification is therefore 0.061 percent or about 0.6 grams per liter. Goats were chosen over cows, sheep and rabbits because of their productivity in producing milk. Goats also are far lower emitters of methane gas than cows.

I recently co-authored an article in Biopharm International that compared the carbon and water footprints of traditional stainless steel biological drug manufacturing facilities with single use plastic alternates. The single use plastic systems had significantly lower water usage and moderately lower carbon footprint. Now that the goat method is FDA approved I will have to research the data, but my hunch is that this method will be hard to beat as goats thrive in arid climates even though they have sweat glands. Goats are raised for their meat as well as their milk. Goat’s milk is naturally homogenized and the cream remains suspended in the milk and does not rise as does cow’s cream, hence we do not have goat cream but we can produce goat butter.

The meat from young goats is called kid, while older animals yield mutton or chevon, not to be mixed up with Chevron. Goat meat is low in cholesterol and is comparable to chicken. The digestive system of goats is able to breakdown just about any organic fodder but they do prefer the tips of trees and woody shrubs. Their favorite hay is alfalfa and therefore goats would vote for Gore over any other politician. As global warming starts to convert Texas into Sudan we may have to start eating more chevon and chevre. If Texas does become Sudan, its capital will be called car-tomb and the state name will change to Sedan. Has the green machine lost his mind thanking old Billy for helping save the planet. I started thinking of goats a couple of weeks ago when I received this email at work that a company in Framingham Massachusetts has received FDA approval for a biological drug that was recovered from goat’s milk in genetically modified goats. The drug is a protein called Antithrombrin and is used to untangle blood clots. There are approximately one in five thousand patients in the USA that have a genetic disorder of not producing antithrombrin and are at high risk during surgeries or pregnancy. The company chose the route of using genetically modified goats rather than modifying ecoli or Chinese Hamster Ovary cells to express the protein. Ecoli and Chinese Hampster Ovary cells are commonly used to make biological drugs that Genentech, Amgen, J&J and other sell.A herd of one hundred and fifty genetically modified goats in Massachusetts express the two hundred and twenty pounds of Antithrombrin protein that otherwise would otherwise have to be produced from every drop of blood that is donated in the USA each year. These are very special goats and I bet you they have special herders who make sure they do not escape from their farm where they are fed better food than your average goat. A female goat produces about eight pounds of milk a day and will do so for approximately three hundred day during lactation. Therefore a single goat will produce two thousand four hundred pounds of milk a year. The herd of one hundred and fifty goats will therefore produce three hundred and sixty thousand pounds of milk a year. The concentration of the Antithrombrin protein in the goat’s milk prior to purification is therefore 0.061 percent or about 0.6 grams per liter. Goats were chosen over cows, sheep and rabbits because of their productivity in producing milk. Goats also are far lower emitters of methane gas than cows.I recently co-authored an article in Biopharm International that compared the carbon and water footprints of traditional stainless steel biological drug manufacturing facilities with single use plastic alternates. The single use plastic systems had significantly lower water usage and moderately lower carbon footprint. Now that the goat method is FDA approved I will have to research the data, but my hunch is that this method will be hard to beat as goats thrive in arid climates even though they have sweat glands. Goats are raised for their meat as well as their milk. Goat’s milk is naturally homogenized and the cream remains suspended in the milk and does not rise as does cow’s cream, hence we do not have goat cream but we can produce goat butter.The meat from young goats is called kid, while older animals yield mutton or chevon, not to be mixed up with Chevron. Goat meat is low in cholesterol and is comparable to chicken. The digestive system of goats is able to breakdown just about any organic fodder but they do prefer the tips of trees and woody shrubs. Their favorite hay is alfalfa and therefore goats would vote for Gore over any other politician. As global warming starts to convert Texas into Sudan we may have to start eating more chevon and chevre. If Texas does become Sudan, its capital will be called car-tomb and the state name will change to Sedan.